Developmental-status-aware transcriptional decomposition establishes a cell state panorama of human cancers
Our study not only provides a general approach to quantifying developmental-status-aware cell states of bulk samples but also constructs an information-rich, biologically interpretable, cell-state panorama of human cancers, enabling diverse translational applications.
Authors
- Yikai Luo (ORCID: https://orcid.org/0000-0001-7589-7981)
- Han Liang (ORCID: https://orcid.org/0000-0001-7633-286X)
Institutions
- The University of Texas MD Anderson Cancer Center (US)
- University of California, San Francisco (US)
- Baylor College of Medicine (US)
- Quantitative BioSciences (US)
Publication Details
- Journal
- Genome Medicine
- Published
- 2024-10-28
- DOI
- https://doi.org/10.1186/s13073-024-01393-6
- Citations
- 1
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 0.23
Funders
- National Institutes of Health
- University of Texas MD Anderson Cancer Center