ZA-II-05, a novel NMDA-receptor antagonist reverses vanadium-induced neurotoxicity in Caenorhabditis elegans (C. elegans)
Treatment with ZA-II-05 significantly preserved cellular integrity, exhibiting a reversal of the detrimental effects induced by vanadium by modulating and preserving the normal function of chemosensory neurons and downstream signaling pathways. This study provides valuable insights into the mechanisms of vanadium-induced neurotoxicity and offers perspectives for developing therapeutic interventions for neurodegenerative diseases related to environmental toxins.
Authors
- Zeynep Ateş‐Alagöz (ORCID: https://orcid.org/0000-0002-5898-9988)
- Taiwo O. Elufioye (ORCID: https://orcid.org/0000-0002-3888-5110)
- Paul L. Chazot (ORCID: https://orcid.org/0000-0002-5453-0379)
- J. Lucas McKay (ORCID: https://orcid.org/0000-0002-8361-8943)
- A. D. Ladagu
- Taidinda T. Gilbert (ORCID: https://orcid.org/0000-0001-7396-2591)
- Funmilayo Eniola Olopade (ORCID: https://orcid.org/0000-0002-0868-9637)
- James Olukayode Olopade (ORCID: https://orcid.org/0000-0002-3470-0801)
- Adeboye Adejare (ORCID: https://orcid.org/0000-0002-7732-8974)
- Madison Fuller
- Toan Luong
- Ethan Halprin
Institutions
- Ankara University (TR)
- University of Ibadan (NG)
- Durham University (GB)
- Saint Joseph's University (US)
Publication Details
- Journal
- BMC Neuroscience
- Published
- 2024-10-28
- DOI
- https://doi.org/10.1186/s12868-024-00902-y
- Citations
- 4
- Primary Topic
- Genetics, Aging, and Longevity in Model Organisms
- Type
- article
- Field-Weighted Citation Impact
- 0.91