Increased serum level of IL-6 predicts poor prognosis in anti-MDA5-positive dermatomyositis with rapidly progressive interstitial lung disease
Our study demonstrated that increased level of serum IL-6 (≥ 13.41pg/mL) and severe lymphopenia were promising predictors of 6-month all-cause mortality and the occurrence of RP-ILD in anti-MDA5-positive DM patients. Furthermore, tracking distinct trajectories of lymphocytes during hospitalization can be utilized to cluster patients.
Authors
- Di Fu (ORCID: https://orcid.org/0000-0001-7218-0387)
- Shanhui Ye
- Qian Qiu (ORCID: https://orcid.org/0000-0002-8281-6526)
- Peng Yang (ORCID: https://orcid.org/0000-0003-0144-2575)
- Hanshi Xu (ORCID: https://orcid.org/0000-0003-1953-2915)
- Suling Liu
- Liuqin Liang (ORCID: https://orcid.org/0000-0002-6614-2613)
- Yuanyuan Niu (ORCID: https://orcid.org/0000-0002-5599-6031)
- Youjun Xiao
Institutions
- Sun Yat-sen University (CN)
- First Affiliated Hospital of Guangzhou Medical University (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- Guangdong Academy of Medical Sciences (CN)
- Guangdong Provincial People's Hospital (CN)
- Southern Medical University (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Arthritis Research & Therapy
- Published
- 2024-10-28
- DOI
- https://doi.org/10.1186/s13075-024-03415-5
- Citations
- 8
- Primary Topic
- Inflammatory Myopathies and Dermatomyositis
- Type
- article
- Field-Weighted Citation Impact
- 3.09
Funders
- Sun Yat-sen University