Optimizing Subretinal Bleb Formation for Visual Streak Involvement in a Porcine Model for Retinal Gene Therapy
Bleb propagation was anisotropic (i.e., directionally biased) and dependent on injection site placement. Superior injection sites led to superior VS detachment. Morphological analysis suggested increased adhesion forces at the VS and superior vascular arcades. This study will aid the planning of surgeries for targeted subretinal delivery in pig models.
Authors
- Jan Motlík
- Jana Juhásová (ORCID: https://orcid.org/0000-0001-7022-6812)
- Andrea Bähr (ORCID: https://orcid.org/0000-0001-8075-8222)
- Nikolai Klymiuk (ORCID: https://orcid.org/0000-0003-3532-1659)
- Immanuel P. Seitz (ORCID: https://orcid.org/0000-0002-3086-6425)
- Taras Ardan (ORCID: https://orcid.org/0000-0002-4354-8354)
- Felix F. Reichel (ORCID: https://orcid.org/0000-0001-9325-5616)
- Yaroslav Nemesh (ORCID: https://orcid.org/0000-0003-3862-9413)
- Štefan Juhás (ORCID: https://orcid.org/0000-0002-2866-0727)
- Tobias Peters (ORCID: https://orcid.org/0000-0002-9187-4904)
- Hanna Auch
- M. Dominik Fischer (ORCID: https://orcid.org/0000-0002-0690-6538)
Institutions
- TUM Klinikum (DE)
- John Radcliffe Hospital (GB)
- University of Oxford (GB)
- Czech Academy of Sciences, Institute of Animal Physiology and Genetics (CZ)
- STZ eyetrial (DE)
- Oxford University Hospitals NHS Trust (GB)
- Technical University of Munich (DE)
- University of Tübingen (DE)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2024-10-28
- DOI
- https://doi.org/10.1167/iovs.65.12.41
- Citations
- 2
- Primary Topic
- Retinal Development and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.47