Anti-human Leukocyte Antigen (HLA) Antibodies in Patients with ESKD on Kidney Transplantation Protocol

Background: Renal transplant is the chosen treatment for the ESRD (End-Stage Renal Disease), so identifying factors possibly associated with complications such as rejection helps to improve renal graft survival. Methods: Retrospective cross-sectional observational study, 150 files were selected; sex, age, medical records, type of renal transplant protocol, record of infectious processes, as well as records of exposure to sensitization factors were reviewed. Results: The average age of the parties was 30 years old, the youngest was 13 years old and the oldest was 75 years old; 46.7% were female and 53.3% were male. 71.3% of patients had transfusion exposure, 30% of patients had previous pregnancy exposure and 8% of the parties had a previous transplant record; 5.3% had diabetes mellitus, and 31.3% of the patients had infections. The 64% of patients were on cadaveric transplant protocols, 36% were on living-donor transplant protocols. Conclusion: The prevalence of anti-HLA antibodies in patients with chronic renal disease undergoing renal transplant protocol at the Hospital General San Juand de Dios was found to be 33.3%. Previous transplant record was associates with anti-HLA antibodies generation in renal transplant protocol patients.