Kidney Disease in Pregnancy and Associated Maternal Outcomes

Background: Maternal hypertension and CKD have increased over the last thirty years. In this study, we evaluate the prevalence of CKD as defined by GFR and proteinuria at the time of pregnancy and its impact on maternal outcomes during pregnancy. Methods: We identified 353,735 adult female members of an integrated healthcare system who had one or more pregnancies from 1/2011 to 6/2023. We stratified the cohort into KDIGO's CKD subcategories and assessed the risk of maternal and prenatal outcomes of patients with versus without CKD. Results: We identified a substantial number of patients with CKD. Clinically and statistically significant differences in maternal and prenatal outcomes exist between those with CKD versus those without. (Please see images for results: Cohort Distrubution and Maternal and Prenatal Outcomes) Conclusion: Understanding individual risks associated with maternal and prenatal outcomes is critical for CKD patients. Additional analysis is being conducted to define risk in individual CKD subgroups and additional predictors of outcome such as comorbidities, age, and ethnicity.Cohort DistrubutionMaternal and Prenatal Outcomes