Transcriptomic analysis of spleen-derived macrophages in response to lipopolysaccharide shows dependency on the MyD88-independent pathway in Chinese giant salamanders (Andrias davidianus)
In contrast to that in other species, macrophage activation in CGS could depend on the non-classical MyD88 pathway in response to bacterial infection. Our study provides insights into the molecular mechanisms regulating CGS antibacterial responses, with implications for disease prevention and understanding immune evolution in amphibians.
Authors
- Yanyan Hao (ORCID: https://orcid.org/0009-0009-7083-1444)
- Mengdi Han (ORCID: https://orcid.org/0000-0002-7552-7398)
- Jing‐Yu Gong
- Hongying Ma (ORCID: https://orcid.org/0000-0001-6846-4125)
- Jia Li (ORCID: https://orcid.org/0000-0002-3606-3949)
- Han Zhang (ORCID: https://orcid.org/0000-0003-0298-8502)
- Wei Jiang (ORCID: https://orcid.org/0000-0003-4229-4345)
- Cheng Fang (ORCID: https://orcid.org/0009-0003-3545-0116)
- Jie Deng
Institutions
- Shaanxi Institute of Zoology (CN)
- Shaanxi Normal University (CN)
Publication Details
- Journal
- BMC Genomics
- Published
- 2024-10-28
- DOI
- https://doi.org/10.1186/s12864-024-10888-w
- Citations
- 1
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.24
Funders
- Natural Science Foundation of Shaanxi Province
- Shaanxi Provincial Science and Technology Department
- Shaanxi Academy of Sciences