Phase I Study of ROR1-Specific CAR-T Cells in Advanced Hematopoietic and Epithelial Malignancies
ROR1 CAR-T cells were well tolerated in most patients. Antitumor activity was observed in CLL but was limited in TNBC and NSCLC. Immunogenicity of the CAR and lack of sustained tumor infiltration were identified as limitations. See related commentary by Kobold, p. 437.
Authors
- David G. Maloney (ORCID: https://orcid.org/0000-0002-8477-6919)
- Jennifer M. Specht (ORCID: https://orcid.org/0000-0003-1484-2113)
- Brandon Seaton
- Hugh Macmillan (ORCID: https://orcid.org/0000-0003-3661-2212)
- Qian Wu (ORCID: https://orcid.org/0000-0002-2292-4816)
- Lauri D. Aicher
- Gabriel O. Cole (ORCID: https://orcid.org/0000-0003-0135-2406)
- Shalini Pullarkat
- Jenna Voutsinas (ORCID: https://orcid.org/0000-0002-7474-4892)
- Evan W. Newell (ORCID: https://orcid.org/0000-0002-2889-243X)
- Cecilia C.S. Yeung (ORCID: https://orcid.org/0000-0001-6799-2022)
- Yun Lo (ORCID: https://orcid.org/0000-0001-8145-3674)
- Sylvia M. Lee (ORCID: https://orcid.org/0000-0002-7425-2230)
- Carla A. Jaeger-Ruckstuhl (ORCID: https://orcid.org/0000-0002-1685-2078)
- Robert H. Pierce (ORCID: https://orcid.org/0000-0002-2677-144X)
- Stanley R. Riddell (ORCID: https://orcid.org/0000-0002-4688-9920)
- Vishaka Muhunthan (ORCID: https://orcid.org/0000-0003-4733-9602)
- Xiaoling Song (ORCID: https://orcid.org/0000-0001-5969-4025)
- Jocelyn H. Wright (ORCID: https://orcid.org/0000-0003-1548-0847)
- Carolina Berger (ORCID: https://orcid.org/0000-0001-9403-5957)
- Teresa S. Hyun (ORCID: https://orcid.org/0009-0009-5682-714X)
Institutions
- Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa (ZA)
- University of Washington (US)
- University of Washington Medical Center (US)
- Fred Hutch Cancer Center (US)
- University of Washington Applied Physics Laboratory (US)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2024-10-28
- DOI
- https://doi.org/10.1158/1078-0432.ccr-24-2172
- Citations
- 31
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 8.76
Funders
- American Cancer Society
- National Cancer Institute