Circadian rhythm disruption modulates enteric neural precursor cells differentiation leading to gastrointestinal motility dysfunction via the NR1D1/NF-κB axis
CRD regulates the differentiation of ENPCs through the NR1D1/NF-κB axis, resulting in dysfunction of the ENS and impaired gastrointestinal motility in mice.
Authors
- Mengke Fan (ORCID: https://orcid.org/0000-0002-9194-5709)
- Qi He (ORCID: https://orcid.org/0000-0002-0427-6210)
- Huiying Shi (ORCID: https://orcid.org/0000-0002-0796-9944)
- Shizhao Xu
- Hailing Yao (ORCID: https://orcid.org/0000-0002-1740-3717)
- Chen Jiang (ORCID: https://orcid.org/0000-0002-2983-7512)
- Yurui Zhang (ORCID: https://orcid.org/0000-0003-3183-4406)
- Rong Lin (ORCID: https://orcid.org/0000-0001-6649-8751)
Institutions
- Union Hospital (HK)
- Wuhan Union Hospital (CN)
- Union Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2024-10-28
- DOI
- https://doi.org/10.1186/s12967-024-05766-8
- Citations
- 4
- Primary Topic
- Gastrointestinal motility and disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.86
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Hubei Province