A new selective force driving metabolic gene clustering
The formation of clusters of functionally related genes in microbial genomes has puzzled microbiologists since their discovery. Here, we suggest that replication, and the copy number variations due to the replisome passage, might play a role in the process through a perturbation in metabolite homeostasis. We provide theoretical support to this hypothesis, and we found that both simulations and genomic analysis support our hypothesis.
Authors
- Marco Fondi
- Christopher Riccardi (ORCID: https://orcid.org/0000-0002-5310-6437)
- Francesco Pini (ORCID: https://orcid.org/0000-0001-5323-8395)
- Pietro Gemo (ORCID: https://orcid.org/0000-0002-4472-9421)
- Matteo Brilli (ORCID: https://orcid.org/0000-0001-9891-4617)
Institutions
- University of Milan (IT)
- University of Florence (IT)
- University of Bari Aldo Moro (IT)
Publication Details
- Journal
- mSystems
- Published
- 2024-10-28
- DOI
- https://doi.org/10.1128/msystems.00960-24
- Primary Topic
- Genomics and Phylogenetic Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ministero dell’Istruzione, dell’Università e della Ricerca