Ruthenium(II) complexes containing PEGylated N-heterocyclic carbene ligands for tunning biocompatibility in the fight against cancer
A synthetic procedure was designed for the preparation and characterization of Ag and Ru complexes containing NHC ligands functionalized with PEG fragments. Stability studies were conducted to gain insight of the species in water and other solvents like DMSO, or with reagents like imidazole as representative group for histidine amino acid. The presence of Cl atoms instead of H in the 4,5 positions of the N-heterocyclic carbene afforded higher water stability. The complexes containing PEG units must be considered inactive as anticancer agents. To enhance the anticancer activity of PEG-containing complexes, the balance between hydrophilicity and hydrophobicity was adjusted using a silane moiety, and an anionic carbosilane dendrimer as a lipophilic carrier.
Authors
- Óscar Barrios (ORCID: https://orcid.org/0000-0002-1862-9793)
- Jesús Cano (ORCID: https://orcid.org/0000-0002-6643-7534)
- Inés Dı́az-Laviada (ORCID: https://orcid.org/0000-0001-9704-4373)
- Alicia Bort (ORCID: https://orcid.org/0000-0003-1490-5823)
- Rafael Gómez (ORCID: https://orcid.org/0000-0001-6448-2414)
- P. Herrera (ORCID: https://orcid.org/0000-0002-6715-8924)
- Avelino Martı́n (ORCID: https://orcid.org/0000-0002-9776-9670)
- Claudia Inclán
Institutions
- Universidad de Alcalá (ES)
- Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (ES)
Publication Details
- Journal
- Journal of Inorganic Biochemistry
- Published
- 2024-10-28
- DOI
- https://doi.org/10.1016/j.jinorgbio.2024.112765
- Citations
- 1
- Primary Topic
- N-Heterocyclic Carbenes in Organic and Inorganic Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 0.25
Funders
- Ministerio de Ciencia e Innovación
- Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina
- Instituto de Salud Carlos III