Hypofractionated radiotherapy with simultaneous integrated boost for localized prostate cancer patients: effects on immune system and prediction of toxicity
Our study analyzed, in the context of hypofractionated radiotherapy in prostate cancer, different parameters of the peripheral immune system. We have highlighted longitudinally the peripheral behavior of the different lymphocyte subpopulations and of a group of 10 cytokines during the first year after RT. One of the analyzed cytokines, such as TGF-β1, has proven to be promising predictive factor of severe late GU toxicity.
Authors
- Antonio Traficante
- Grazia Lazzari
- Teodora Statuto
- Serena Cabaro
- Giovanni Calice (ORCID: https://orcid.org/0000-0002-2545-1401)
- Fiorella D’Auria (ORCID: https://orcid.org/0000-0002-3030-1651)
- Vittoria D’Esposito (ORCID: https://orcid.org/0000-0002-3675-8062)
- Pietro Formisano (ORCID: https://orcid.org/0000-0001-7020-6870)
- Gabriella Bianchino (ORCID: https://orcid.org/0000-0002-6553-6063)
- Luciana Valvano (ORCID: https://orcid.org/0000-0002-6382-7318)
- Luciana Rago
- Antonella Bianculli (ORCID: https://orcid.org/0000-0002-0643-5684)
Institutions
- Centro di Riferimento Oncologico della Basilicata (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- University of Naples Federico II (IT)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-10-28
- DOI
- https://doi.org/10.3389/fimmu.2024.1457839
- Citations
- 1
- Primary Topic
- Prostate Cancer Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.42
Funders
- Ministero della Salute