A genome-wide association study identifies genetic determinants of hemoglobin glycation index with implications across sex and ethnicity
Many HGI-associated SNPs were distinct from those associated with fasting plasma glucose or HbA1c, lending further support for HGI as a distinct biomarker of diabetes complications. The results of this first evaluation of the genetic etiology of HGI indicate that it is highly heritable and point to heterogeneity by sex and race.
Authors
- Shuqian Liu
- Changwei Li (ORCID: https://orcid.org/0000-0002-9203-304X)
- Alessandro Doria (ORCID: https://orcid.org/0000-0002-3830-4304)
- Vivian Fonseca (ORCID: https://orcid.org/0000-0002-3381-7151)
- John B. Buse (ORCID: https://orcid.org/0000-0002-9723-3876)
- James M. Hempe (ORCID: https://orcid.org/0000-0001-7038-7499)
- Joseph H. Breeyear (ORCID: https://orcid.org/0000-0002-6179-0515)
- Tanika N. Kelly (ORCID: https://orcid.org/0000-0002-7348-4451)
- Alison A. Motsinger‐Reif (ORCID: https://orcid.org/0000-0003-1346-2493)
- Daniel Miller Rotroff (ORCID: https://orcid.org/0000-0003-0553-3220)
- Mengyao Shi (ORCID: https://orcid.org/0000-0002-5883-0416)
- Farida S. Akhtari
- John S. House (ORCID: https://orcid.org/0000-0002-8447-7871)
- Josyf C. Mychaleckyi
- Violet Evans
Institutions
- University of North Carolina at Chapel Hill (US)
- Tulane University (US)
- Louisiana State University (US)
- Joslin Diabetes Center (US)
- National Institutes of Health (US)
- Cleveland Clinic (US)
- Harvard University (US)
- Cleveland Clinic Lerner College of Medicine (US)
- National Institute of Environmental Health Sciences (US)
- University of Virginia (US)
- Case Western Reserve University (US)
- Louisiana State University Health Sciences Center New Orleans (US)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2024-10-28
- DOI
- https://doi.org/10.3389/fendo.2024.1473329
- Citations
- 1
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.55
Funders
- National Institute of Environmental Health Sciences