Characterization and comparation of toxicity between natural realgar and artificially optimized realgar
The differences between natural realgar and artificially optimized realgar were successfully distinguished through several methods. <i>In vitro</i> experiments showed that As is the main component exerting their medicinal effects. <i>In vivo</i> toxicity tests demonstrated that at higher dose, artificially optimized realgar exhibited significantly higher toxicity, suggesting that natural and artificially optimized realgar have different toxic properties.
Authors
- Ming Wei
- Raorao Li
- Xuelei Xin (ORCID: https://orcid.org/0000-0001-6009-2996)
- Nanxi Huang
- Lu Luo (ORCID: https://orcid.org/0000-0002-5601-0801)
- Shuangrong Gao
- GU Xue-zhu
- Qiaochu Wang (ORCID: https://orcid.org/0000-0002-4303-0950)
Institutions
- Union Hospital (HK)
- Georgetown University (US)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2024-10-28
- DOI
- https://doi.org/10.3389/fphar.2024.1476139
- Citations
- 3
- Primary Topic
- Phytochemicals and Medicinal Plants
- Type
- article
- Field-Weighted Citation Impact
- 2.15
Funders
- National Natural Science Foundation of China
- China Academy of Chinese Medical Sciences