Divergent Synthesis of Enynals and Dihydrobenzo[<i>f</i>]isoquinolines via Deoxyalkynylation of Enaminones Enabled by the Cooperative Action of Tf<sub>2</sub>O/Pd/Cu
A variety of enynals and dihydrobenzo[<i>f</i>]<i>iso</i>quinolines were effectively synthesized with favorable functional group compatibility via deoxyalkynylation of enaminones enabled by the cooperative action of Tf<sub>2</sub>O/Pd/Cu. The reaction system demonstrated the ability to be expanded to the deoxyarylation/deoxyaryloxylation of enaminones with arylboronic acids or phenols, facilitating the efficient formation of C-C/C-O bonds and showcasing the practicality and versatility of the methodology.
Authors
- Xiaohan Zhang (ORCID: https://orcid.org/0000-0002-3693-8194)
- Mengping Guo
- Yucai Jiang (ORCID: https://orcid.org/0009-0003-8516-4505)
- Changyuan Zhang (ORCID: https://orcid.org/0000-0001-9051-0167)
- Lulu Chen (ORCID: https://orcid.org/0000-0003-0167-4632)
- Jianping Lin (ORCID: https://orcid.org/0000-0003-3767-3711)
- Yiming Xu (ORCID: https://orcid.org/0009-0003-5533-1747)
- Jiakai Tian
- Lu Yu (ORCID: https://orcid.org/0009-0000-4722-4587)
Institutions
- Yichun University (CN)
- Putian University (CN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2024-10-28
- DOI
- https://doi.org/10.1021/acs.joc.4c01603
- Citations
- 4
- Primary Topic
- Advanced Synthetic Organic Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 1.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Fujian Province