Mizhuo Guanchangye enema delays the decline of renal function in rats with chronic kidney disease by intervening in the TLR4/MyD88/NF-κB pathway
MZGCY significantly reduces the levels of intestinal toxins and inflammatory factors in the serum of CKD rats by interfering with the TLR4/MyD88/NF-κB signaling pathway, thereby improving intestinal and renal pathological changes and delaying CKD progression. This study demonstrates that MZGCY has significant renal protective effects, providing a new potential approach for CKD treatment.
Authors
- Binhua Liang (ORCID: https://orcid.org/0000-0002-1108-6407)
- Naijing Ye
- Han Li (ORCID: https://orcid.org/0000-0002-1289-756X)
- Peng Xu (ORCID: https://orcid.org/0000-0002-4581-7204)
- Xiaomei Zhang
- Xu Fang (ORCID: https://orcid.org/0000-0003-4507-1294)
Institutions
- Tongde Hospital of Zhejiang Province (CN)
- Guangxi Medicinal Botanical Garden (CN)
- The Third Affiliated Hospital of Zhejiang Chinese Medical University (CN)
- First Affiliated Hospital of Henan University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2024-10-28
- DOI
- https://doi.org/10.3389/fmed.2024.1454506
- Citations
- 1
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.24