Clinical Diagnostic Value and Accuracy of Microbiological Testing for Pulmonary Aspergillosis Infection

Objective: To analyze the clinical diagnostic value and accuracy of microbiological testing for pulmonary aspergillosis infection.Methods: Sixty patients suspected of having pulmonary aspergillosis infection from January 2023 to June 2024 were selected. All selected patients underwent sputum culture test, galactomannan test (GM test), and 1,3-β-D-glucose (BDG) test (referred to as G test). Pathological histology examination was used as the gold standard to evaluate the diagnostic value and accuracy of sputum culture test, GM test, and G test in pulmonary aspergillosis infection. Results: In this study, histopathological examination of 60 patients showed 35 positive cases and 25 negative cases of pulmonary aspergillosis infection. The sputum culture test results showed that there were 34 positive cases, 26 negative cases, 7 false positives, and 6 false negatives of pulmonary aspergillosis infection. The GM test results showed that there were 34 positive cases, 26 negative cases, 3 false positives, and 2 false negatives of pulmonary aspergillosis infection. The G test results showed that there were 34 positive cases, 26 negative cases, 8 false positives, and 7 false negatives of pulmonary aspergillosis infection. The sensitivity, specificity, accuracy, positive predictive value, and negative predictive value of the GM test were significantly higher than those of the sputum culture test and G test (P<0.05). Conclusion: The diagnostic value of the GM test in pulmonary aspergillosis infection is higher than the sputum culture test and G test, and it can be widely used.