Frequency of periprocedural myocardial injury and infarction stratified by cardiac troponin I and T

Abstract Background There are different definitions of periprocedural myocardial infarction (PPMI) both in terms of thresholds for cardiac biomarkers and the ancillary criteria for myocardial ischemia. Cardiac Troponin I (cTnI) and cardiac Troponin T (cTnT) are used interchangeably to diagnose PPMI. Objectives This study evaluated the frequency of periprocedural myocardial injury and infarction as defined by the Society of Cardiovascular Angiography & Interventions (SCAI), the Academic Research Consortium-2 (ARC-2), and the 4th Universal definition of MI (4UDMI) stratified using cTnT versus cTnI, among patients with chronic coronary syndrome (CCS) and unstable angina. Results Among 830 patients, PPMI rates according to the SCAI, ARC2 and 4UDMI criteria were 4.34%, 2.05%, and 4.94% respectively, with higher rates seen for all definitions when using cTnI versus cTnT (SCAI: 9.84% vs. 1.91%, p<0.001; ARC 2: 3.15% vs. 1.56%, p=0.136; and 4UDMI 5.91% vs. 4.51%, p=0.391). Minor and major periprocedural myocardial injury was respectively observed in 58.31% and 27.10% of patients, with rates of both significantly higher when using cTnI versus cTnT (Minor: 69.29% vs. 53.47%, p<0.001, Major: 49.21% vs. 17.36%, p<0.001). Conclusions Among patients with CCS and unstable angina, PPMIs defined by SCAI occurred more frequently when using cTnI as opposed to cTnT, whereas the type of troponin had no impact on the incidence of PPMIs according to the ARC-2 and 4UDMI