Correlation between portal hypertension and somatic constitution: rationale behind the concept

Portal hypertension, one of the serious consequences of liver cirrhosis, contributes to the aggravation of complications such as ascites, varicose veins of the esophagus, stomach and anterior abdominal wall, splenomegaly and hepatic encephalopathy. This review article evaluates the biomolecular mechanisms that determine the role of human constitutional characteristics as a prognostic factor for portal hypertension and the course of liver cirrhosis. A search for publications and an analysis of literary sources was conducted using the PubMed and eLibrary.ru databases, mainly for the last 10 years. A search for publications was performed by keywords, as a result of which 6418 works were found (3623 full-text papers), 108 publications were studied, of which 23 publications were referenced. The analysis of papers resulted in the identification of one of the leading biomolecular mechanisms that determine the correlation between the constitutional features of the body, namely, an increased endomorphic component, and the risk of developing portal hypertension. The greatest influence on the endomorphic component of body composition derives from proinflammatory factors, insulin resistance and the absence of insulin sensitization syndrome caused by food intake.