Association of human leucocyte antigen loci with vaccine‐induced immune thrombotic thrombocytopenia: Potential role of the interaction between platelet factor 4‐derived peptides and <scp>MHC</scp>‐<scp>II</scp>
No risk factors have been identified for vaccine-induced immune thrombotic thrombocytopenia (VITT) so far. The aim of this study was to identify human leucocyte antigen (HLA) alleles potentially associated with VITT susceptibility. Specific HLA class II alleles were detected with significantly higher frequency in VITT patients compared with Italian controls: DPB1*17:01, DQA1*05:01, and DRB1*11:04. In silico analysis revealed increased affinity of DRB1*11:04 for a platelet factor 4 (PF4)-derived peptide, ITSLEVIKA, that contains two amino acids present in the specific binding site of anti-PF4 antibodies from VITT patients. Our findings show for the first time a genetic predisposition to developing anti-PF4 antibodies in response to Ad-vector vaccines.
Authors
- Jorge Di Paola (ORCID: https://orcid.org/0000-0002-1461-2871)
- Paolo Gresele (ORCID: https://orcid.org/0000-0001-5365-8445)
- Matthew T. Rondina (ORCID: https://orcid.org/0000-0003-3455-3730)
- Rita Santoro (ORCID: https://orcid.org/0000-0002-5081-8201)
- Erica De Candia (ORCID: https://orcid.org/0000-0003-0942-2819)
- Brooke Sadler (ORCID: https://orcid.org/0000-0002-3268-3809)
- Anna Falanga (ORCID: https://orcid.org/0000-0002-5007-3457)
- Egidio Imbalzano (ORCID: https://orcid.org/0000-0003-2656-5467)
- Gaetano Vaudo (ORCID: https://orcid.org/0000-0002-3176-2038)
- Lucia Stefanini (ORCID: https://orcid.org/0000-0001-7420-301X)
- Gian Marco Podda (ORCID: https://orcid.org/0000-0002-1791-8905)
- Lilian Antunes Heck
- Rossella Marcucci (ORCID: https://orcid.org/0000-0001-9549-7176)
- Andrea Boccatonda (ORCID: https://orcid.org/0000-0001-9303-7790)
- Eleonora Petito (ORCID: https://orcid.org/0000-0003-4921-8687)
- Loredana Bury (ORCID: https://orcid.org/0000-0003-0333-0948)
- Marta Panella (ORCID: https://orcid.org/0000-0002-4842-2371)
- Maria Costanza Turi
- Patrizia Sciancalepore
- Igor Florio (ORCID: https://orcid.org/0009-0001-9590-4162)
- Patrizia Noris (ORCID: https://orcid.org/0000-0002-3374-7325)
Institutions
- University of Messina (IT)
- University of Rome Tor Vergata (IT)
- University of Milan (IT)
- Washington University in St. Louis (US)
- University of Utah (US)
- University of Pavia (IT)
- University of Perugia (IT)
- Agostino Gemelli University Polyclinic (IT)
- Ospedale di Bolzano (IT)
- Ospedale Papa Giovanni XXIII (IT)
- Geriatric Research Education and Clinical Center (US)
- Ospedale San Paolo (IT)
- Azienda USL di Bologna (IT)
- Azienda Ospedaliera Pugliese Ciaccio (IT)
- Ospedale SS. Annunziata (IT)
- Policlinico San Matteo Fondazione (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- ASM Terni (Italy) (IT)
- Azienda Ospedaliera Nazionale SS. Antonio e Biagio e Cesare Arrigo (IT)
- George E. Wahlen Department of VA Medical Center (US)
- University of Florence (IT)
- Sapienza University of Rome (IT)
Publication Details
- Journal
- British Journal of Haematology
- Published
- 2024-10-27
- DOI
- https://doi.org/10.1111/bjh.19838
- Citations
- 10
- Primary Topic
- Platelet Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 4.54
Funders
- Fondazione Umberto Veronesi