Functional activity of thyroid gland follicular cells after exposure to tartrazine, bone trauma and administration of selenase

The food azo dye tartrazine requires further study to understand the safety of its effects and study the adaptation of the body against this background, in particular after bone injury, as well as ways to correct these changes. The purpose of the work was to determine the functional activity of follicular endocrinocytes on electronograms after long-term use of tartrazine and tibiae trauma with or without administration of selenase. The study involved 36 mature white rats (rats of the 1st group were injected with saline solution for 2 months, the 2nd group – a solution of tartrazine at a dose of 1500 mg/kg, the 3rd group – tartrazine and selenase at a dose of 40 mcg/kg), with subsequent tibiae trauma. On 3rd day, hypofunction of follicular cells was determined in rats of all groups, (17,20 ± 0,25), (12,90 ± 0,23), (13,80 ± 0,20) points, and by 24th day only in rats of 1st group recovery of their function was detected, (34,40 ± 0,22).