Assessment of the effect of solid herbal extract of primula veris l on the physical performance of rats after chronic alcohol intoxication

The aim of this study was to evaluate the effect of solid herbal extract of Primula Veris L. and comparison drugs phenotropil and mildronate on the physical performance of female rats after chronic alcohol intoxication (CAI). CAI was modeled by replacing drinking water for 6 months with a 10 % solution of ethyl alcohol with sucrose (50 g/l). At the age of 16 months, the “Rotarod performance test”, “The horizontal rope walking test” and “Forced swim test with weight load” were performed. After CAI, rats show a deterioration in coordination and motor activity, a decrease in muscle strength and aerobic-anaerobic endurance. Solid herbal extract of Primula Veris L., phenotropil and mildronate contributed to an increase in the physical performance of animals after CAI.