Lactobacillaceae differentially impact butyrate-producing gut microbiota to drive CNS autoimmunity
Our data highlight a potential mechanism for reduced SCFAs and their producers in MS through depletion by other members of the gut microbiome, demonstrating that interactions between microbiota can impact CNS autoimmunity in a diet-dependent manner. These data suggest that therapeutic restoration of SCFA levels in MS may require not only dietary intervention, but also modulation of the gut microbiome.
Authors
- Josephine J. Kennedy
- Dimitry N. Krementsov (ORCID: https://orcid.org/0000-0003-2709-7466)
- Matthew Scarborough (ORCID: https://orcid.org/0000-0001-8027-7349)
- Eamonn R. Heney
- Korin Eckstrom (ORCID: https://orcid.org/0000-0002-6941-7627)
- Lucinda C. Toppen (ORCID: https://orcid.org/0009-0006-5079-4656)
- Theresa L. Montgomery
Institutions
- University of Vermont (US)
- University of Vermont Medical Center (US)
Publication Details
- Journal
- Gut Microbes
- Published
- 2024-10-27
- DOI
- https://doi.org/10.1080/19490976.2024.2418415
- Citations
- 39
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 9.12
Funders
- National Institutes of Health
- National Institute of Neurological Disorders and Stroke