Increased Calcification by Erythrophagocytosis in Aortic Valvular Interstitial Cells
Our results identify erythrophagocytosis by VIC, leading to iron accumulation and enhanced calcification through ferroptosis. This may be a crucial component of the pathophysiological mechanisms that links ILH to valvular calcification and accelerated aortic stenosis progression.
Authors
- Sven‐Christian Pawelzik (ORCID: https://orcid.org/0000-0001-8704-6607)
- Anders Franco‐Cereceda (ORCID: https://orcid.org/0000-0002-3427-9455)
- Magnus Bäck (ORCID: https://orcid.org/0000-0003-0853-5141)
- Zihan Qin
Institutions
- Karolinska University Hospital (SE)
- Science for Life Laboratory (SE)
- Karolinska Institutet (SE)
Publication Details
- Journal
- ESC Heart Failure
- Published
- 2024-10-27
- DOI
- https://doi.org/10.1002/ehf2.15132
- Citations
- 4
- Primary Topic
- Cardiac Valve Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- Hjärt-Lungfonden
- Karolinska Institutet
- Vetenskapsrådet
- China Scholarship Council
- Stiftelsen Professor Nanna Svartz Fond