Cytoplasmic HMGB2 orchestrates CALR translocation in the course of immunogenic cell death
A recent in vitro study showed that pharmacological inhibition of the nuclear export receptor XPO1 suppresses oxaliplatin-induced nuclear release of HMGB1 and HMGB2, as well as the translocation of CALR to the plasma membrane. Moreover, cell-targeted-HMGB2 protein potently induced CALR exposure, even in the absence of oxaliplatin.
Authors
- Oliver Kepp (ORCID: https://orcid.org/0000-0002-6081-9558)
- Peng Liu (ORCID: https://orcid.org/0000-0002-1682-9222)
- Liwei Zhao
- Guido Kroemer
Institutions
- Inserm (FR)
- Institut Universitaire de France (FR)
- Université Paris Cité (FR)
- Institut Gustave Roussy (FR)
- Sorbonne Université (FR)
- Centre de Recherche des Cordeliers (FR)
- Institut National du Cancer (FR)
Publication Details
- Journal
- OncoImmunology
- Published
- 2024-10-26
- DOI
- https://doi.org/10.1080/2162402x.2024.2421028
- Citations
- 2
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 0.48
Funders
- Association pour la Recherche sur le Cancer
- Seerave Foundation
- Equipex
- European Commission
- Agence Nationale de la Recherche
- Fondation pour la Recherche Médicale
- Ligue Contre le Cancer
- Centre National de la Recherche Scientifique
- Institut Universitaire de France
- Institut National Du Cancer
- Labex Immuno-Oncology
- H2020 European Research Council