Programmable Artificial Skins Accomplish Antiscar Healing with Multiple Appendage Regeneration
Functional appendage regeneration is essential for skin rehabilitation, but it has always failed by current existing healing approaches, owing to their inefficacy in preventing disfiguring scars. In this study, a novel regeneration-directing artificial skin (RDAS) system is presented, which is based on the rational design of multi-layered hydrogels that closely mimic natural skin matrices. By leveraging the programmability and architectural rigidity of DNA components, without the need for exogenous cell transplantation, such RDAS effectively minimizes tissue fibrosis by accurately guiding the regenerative process in wound fibroblasts, enabling rapid scarless wound repair, restoration of dermal function, and successful in situ regeneration of multiple appendages, such as hair follicles (HFs), sebaceous glands (SGs), and sweat glands (SwGs). Therefore, the RDAS offers a cell-free antiscarring therapeutic strategy for regenerative wound healing, resulting in improved outcomes. This innovative approach holds great potential for future clinical applications and burn rehabilitation.
Authors
- Jiangbing Xiang
- Yuanchen Dong (ORCID: https://orcid.org/0000-0002-0653-7760)
- Yiyue Hong (ORCID: https://orcid.org/0009-0001-2348-420X)
- Mengyang Wang (ORCID: https://orcid.org/0000-0003-2406-9996)
- Huanhuan Gao (ORCID: https://orcid.org/0000-0002-4701-7913)
- Xiaoyan Sun (ORCID: https://orcid.org/0000-0001-7168-1358)
- Ziwei Shi (ORCID: https://orcid.org/0000-0002-9276-6948)
- Xinling Yang (ORCID: https://orcid.org/0000-0002-0118-402X)
- Mingchen Xiong
- Xiaobing Fu (ORCID: https://orcid.org/0000-0002-2465-1700)
- Hongliang Zhang (ORCID: https://orcid.org/0000-0002-9295-8683)
- Dongsheng Liu (ORCID: https://orcid.org/0000-0002-2583-818X)
- Yingying Li
- Yan Li
- Huating Chen (ORCID: https://orcid.org/0000-0002-8693-8184)
- Shuaifei Ji
- Wei Pi
Institutions
- Chinese Academy of Sciences (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Chinese PLA General Hospital (CN)
- Institute of Chemistry (CN)
- State Key Laboratory of Chemical Engineering (CN)
- University of Chinese Academy of Sciences (CN)
- Nanjing University (CN)
- Tsinghua University (CN)
Publication Details
- Journal
- Advanced Materials
- Published
- 2024-10-25
- DOI
- https://doi.org/10.1002/adma.202407322
- Citations
- 30
- Primary Topic
- Wound Healing and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 7.50
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China