Synthesis of [6,5,5]Ring‐Fused Tricyclic Triazoles by Copper‐Promoted Double Cyclization
Abstract Ring‐fused 1,2,3‐triazoles are important biologically active compounds and synthetic intermediates. Known methods for their synthesis are limited mostly to triazoles fused to six‐membered or larger rings. Herein we disclose a synthetic approach to triazoles fused to five‐membered rings based on copper(I)‐promoted double cyclization consisting of azide‐alkyne cycloaddition, followed by cross coupling to aryl iodides.
Authors
- Petr Beier (ORCID: https://orcid.org/0000-0002-0888-7465)
- Václav Matoušek (ORCID: https://orcid.org/0000-0002-8289-3169)
- Martin Pošta (ORCID: https://orcid.org/0000-0001-9134-5204)
- Blanka Klepetářová (ORCID: https://orcid.org/0000-0003-3916-7839)
- Chiara Volpe
- Margarita Dmitrieva
Institutions
- Czech Academy of Sciences, Institute of Organic Chemistry and Biochemistry (CZ)
Publication Details
- Journal
- European Journal of Organic Chemistry
- Published
- 2024-10-25
- DOI
- https://doi.org/10.1002/ejoc.202400736
- Citations
- 1
- Primary Topic
- Click Chemistry and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.25
Funders
- Grantová Agentura České Republiky
- Akademie Věd České Republiky