Clinical Application of Metagenomic Next-Generation Sequencing in Sepsis Patients with Early Antibiotic Treatment
With increased antibiotic exposure time, the positive rate of culture testing significantly decreased (44.44% vs 59.52% vs 35.71%, <i>P</i> = 0.031), whereas the positive rate of mNGS remained stable (77.78% vs 88.10% vs 92.86%, <i>P</i> = 0.557). mNGS demonstrated less susceptibility to antibiotic exposure. Early mNGS detection positively impacted the prognosis of sepsis patients.
Authors
- Zhaoning Wang (ORCID: https://orcid.org/0000-0002-0290-4746)
- Yongsong Chen (ORCID: https://orcid.org/0000-0002-8208-4951)
- Chongyue Chen
- Yongru Chen (ORCID: https://orcid.org/0000-0001-6134-3355)
- Yafeng Zheng (ORCID: https://orcid.org/0000-0002-1132-3433)
- Wei Chen (ORCID: https://orcid.org/0000-0002-7592-2910)
- Zhiming Cai
- Yuxin Guo (ORCID: https://orcid.org/0000-0002-3473-3240)
- Wei Gai (ORCID: https://orcid.org/0009-0002-1016-4300)
Institutions
- BGI Group (China) (CN)
- Ministry of Education of the People's Republic of China (CN)
- Shantou University (CN)
- First Affiliated Hospital of Shantou University Medical College (CN)
- Shenzhen University Health Science Center (CN)
- Shenzhen Second People's Hospital (CN)
Publication Details
- Journal
- Infection and Drug Resistance
- Published
- 2024-10-01
- DOI
- https://doi.org/10.2147/idr.s485102
- Citations
- 8
- Primary Topic
- Bacterial Identification and Susceptibility Testing
- Type
- article
- Field-Weighted Citation Impact
- 3.05