Efficacy Safety and Acceptibility of Intralesional Bleomycin in the Treatment of Ungual and Resistant Palmoplantar Warts

Aim and Objectives: This study was conducted to evaluate the role of intralesional (IL) bleomycin injection in resistant ungual and palmoplantar warts to know its efficacy and safety. Methodology: It was a Prospective observational study in which Seventeen Patients who met the inclusion and exclusion criteria were included comprising ten males and seven females. Injection Bleomycin was injected to the base of each wart until the lesion was blanched. The amount of injection was determined based on the size of the wart. Patients were checked on for eschar paring at two weeks and, if required, a second dose of bleomycin injection at four weeks. Results: Seventeen patients were enrolled in the study, comprising ten males and seven females, with age between 19 to 51 years. Wart clearance after four weeks of first dose were seen in seven patients, significant response in four, mild response in five patients and no response in one patient. After twelve weeks of treatments fourteen had complete clearance of warts, two had Significant clearance and one patient did not show any response. Most common side effect encountered was pain and burning sensation. Conclusion: Intralesional bleomycin appears an effective and safe treatment for resistant and difficult sites warts even at health institute with limited resources, as no specialized equipment is needed unlike cryotherapy or pulsed dye laser