RHOF promotes Snail1 lactylation by enhancing PKM2-mediated glycolysis to induce pancreatic cancer cell endothelial–mesenchymal transition
RHOF plays an oncogenic role in PC. c-Myc is upregulated by RHOF and promotes PKM2 transcription. PKM2 further induces glycolysis, and the lactate produced by glycolysis causes the lactylation of Snail1, ultimately promoting EMT.
Authors
- Han Liu (ORCID: https://orcid.org/0000-0002-0022-1861)
- Yong Yi (ORCID: https://orcid.org/0000-0003-4664-9692)
- Shuhai Chen (ORCID: https://orcid.org/0000-0003-0734-5848)
- Feng Li (ORCID: https://orcid.org/0000-0002-3064-7548)
- Lei Wang (ORCID: https://orcid.org/0000-0002-7584-8802)
- Rui Zhao (ORCID: https://orcid.org/0000-0002-3069-7940)
- Jianwei Xu
- Dong Wu
Institutions
- Shandong University (CN)
- Qilu Hospital of Shandong University (CN)
Publication Details
- Journal
- Cancer & Metabolism
- Published
- 2024-10-26
- DOI
- https://doi.org/10.1186/s40170-024-00362-2
- Citations
- 31
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 8.84
Funders
- Natural Science Foundation of Shandong Province