Gestational diabetes and future cardiovascular diseases: associations by sex-specific genetic data
This study demonstrated a suggestive causal relationship between genetic predisposition to gestational diabetes mellitus and the risk of coronary artery disease, which was mainly mediated by Type 2 diabetes and hypertension. These findings highlight targeting modifiable cardiometabolic risk factors may reduce the risk of coronary artery disease in women with a history of gestational diabetes mellitus.
Authors
- Z. J. Chen
- H. M. Liu (ORCID: https://orcid.org/0000-0002-0268-726X)
- Huiying Liang (ORCID: https://orcid.org/0000-0003-0407-0383)
- Shan Tu (ORCID: https://orcid.org/0000-0003-0071-3409)
- Yeshen Zhang
- Chongyang Duan (ORCID: https://orcid.org/0000-0001-7973-0353)
- Yining Dai (ORCID: https://orcid.org/0000-0003-2262-7982)
- Siyu Kong (ORCID: https://orcid.org/0009-0002-3291-2760)
- Xinyang Long (ORCID: https://orcid.org/0000-0001-9584-5898)
- Fei Ye
- Zhihui Zhang (ORCID: https://orcid.org/0000-0003-3111-2665)
- Yu He
- Huixian Li (ORCID: https://orcid.org/0000-0001-5722-8602)
- Liu Y (ORCID: https://orcid.org/0000-0001-8568-623X)
- Ning Tan (ORCID: https://orcid.org/0009-0001-0589-5822)
- Pengcheng He
- Weikun Chen (ORCID: https://orcid.org/0000-0002-1004-1602)
- Shijie Yu
- Ling Xue (ORCID: https://orcid.org/0000-0002-9945-5499)
- Wenzhi Luo
Institutions
- Central South University (CN)
- Guangdong Academy of Medical Sciences (CN)
- Guangdong Provincial People's Hospital (CN)
- Third Xiangya Hospital (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- European Heart Journal
- Published
- 2024-10-25
- DOI
- https://doi.org/10.1093/eurheartj/ehae706
- Citations
- 16
- Primary Topic
- Birth, Development, and Health
- Type
- article
- Field-Weighted Citation Impact
- 17.75
Funders
- Capital Medical University
- Guangdong Provincial People's Hospital
- High-level Hospital Construction Project of Guangdong Provincial People's Hospital