<i>APOL1</i> Bi- and Monoallelic Variants and Chronic Kidney Disease in West Africans
In this study, monoallelic <i>APOL1</i> variants were associated with 18% higher odds of CKD and 61% higher odds of focal segmental glomerulosclerosis; biallelic <i>APOL1</i> variants were associated with 25% higher odds of CKD and 84% higher odds of focal segmental glomerulosclerosis. (Funded by the National Human Genome Research Institute and others.).
Authors
- Samuel Ajayi (ORCID: https://orcid.org/0000-0003-4395-9222)
- Frank C. Brosius (ORCID: https://orcid.org/0000-0002-4244-8335)
- Akinlolu Ojo (ORCID: https://orcid.org/0000-0002-5198-9854)
- Aliyu Abdu (ORCID: https://orcid.org/0000-0001-9815-2739)
- Winfred W. Williams (ORCID: https://orcid.org/0000-0001-9984-7102)
- Alexander K. Nyarko (ORCID: https://orcid.org/0000-0002-9923-360X)
- Ogochukwu Okoye (ORCID: https://orcid.org/0000-0002-4993-0474)
- Martin R. Pollak (ORCID: https://orcid.org/0000-0002-2396-9725)
- Adaobi Solarin (ORCID: https://orcid.org/0000-0002-2594-5815)
- Cheryl Ann Winkler (ORCID: https://orcid.org/0000-0001-5552-0917)
- Rasheed Gbadegesin (ORCID: https://orcid.org/0000-0001-5641-6644)
- Anita Ghansah (ORCID: https://orcid.org/0000-0003-4639-1249)
- Victoria Adabayeri
- Jacob Plange‐Rhule (ORCID: https://orcid.org/0000-0002-3742-2616)
- B. I. Freedman
- Adanze Onyenonachi Asinobi (ORCID: https://orcid.org/0000-0002-6227-6729)
- Ifeoma Ulasi (ORCID: https://orcid.org/0000-0001-7783-3025)
- Dwomoa Adu (ORCID: https://orcid.org/0000-0002-2606-2117)
- David Burke (ORCID: https://orcid.org/0000-0002-2564-7949)
- Charlotte Osafo (ORCID: https://orcid.org/0000-0002-2648-626X)
- Rulan S. Parekh (ORCID: https://orcid.org/0000-0001-6313-5752)
- B. Collins (ORCID: https://orcid.org/0000-0001-8257-2755)
- Jillian Wilson
- Vincent Boima (ORCID: https://orcid.org/0000-0002-0562-6307)
- Muhammad Makusidi (ORCID: https://orcid.org/0000-0002-0863-5364)
- Richard Cooper (ORCID: https://orcid.org/0000-0002-3037-7779)
- Ivy Ekem (ORCID: https://orcid.org/0000-0003-2426-314X)
- Timothy Olusegun Olanrewaju (ORCID: https://orcid.org/0000-0002-8944-4198)
- Adebowale Adeyemo (ORCID: https://orcid.org/0000-0002-3105-3231)
- Sampson Antwi (ORCID: https://orcid.org/0000-0003-0957-6105)
- Manmak Mamven (ORCID: https://orcid.org/0000-0003-3229-6689)
- Matthias Kretzler (ORCID: https://orcid.org/0000-0003-4064-0582)
- Milind A. Phadnis (ORCID: https://orcid.org/0000-0001-6472-9325)
- Bamidele O. Tayo (ORCID: https://orcid.org/0000-0002-2277-3958)
- Titilayo O. Ilori (ORCID: https://orcid.org/0000-0002-7457-0618)
- Babatunde Lawal Salako (ORCID: https://orcid.org/0000-0002-0963-7302)
- Fatiu A. Arogundade (ORCID: https://orcid.org/0000-0001-6802-6651)
- Olukemi K. Amodu (ORCID: https://orcid.org/0000-0003-1477-4229)
- Adebowale Ademola (ORCID: https://orcid.org/0000-0001-9465-2744)
- Jeffrey B. Hodgin (ORCID: https://orcid.org/0000-0003-0534-3048)
- Michael Mate-Kole
- Toyin Amira
- Nicholette D. Palmer
- Olugbenga Awobusuyi
- Paul L. Kimmel
- Yemi Raheem Raji
- Jill Smith
- Uzoma Odenigbo
- Celia I. Agwai
Institutions
- University of Ibadan (NG)
Publication Details
- Journal
- New England Journal of Medicine
- Published
- 2024-10-26
- DOI
- https://doi.org/10.1056/nejmoa2404211
- Citations
- 63
- Primary Topic
- Renal Diseases and Glomerulopathies
- Type
- article
- Field-Weighted Citation Impact
- 21.37
Funders
- U.S. Department of Health and Human Services
- National Institutes of Health
- University of Kansas Medical Center
- Medical School, University of Michigan
- Health Sciences, University of Arizona
- National Human Genome Research Institute
- National Cancer Institute
- National Institute of Diabetes and Digestive and Kidney Diseases
- National Center for Advancing Translational Sciences
- Division of Cancer Epidemiology and Genetics, National Cancer Institute