Exosomes derived from apical papilla stem cells improve NASH by regulating fatty acid metabolism and reducing inflammation
After exosomes treatment, the weight gain and liver damage induced by HFD were significantly reduced. Additionally, hepatic fat accumulation was markedly alleviated. Mechanistically, exosomes treatment promoted the expression of genes involved in hepatic fatty acid oxidation and transport, while simultaneously suppressing genes associated with fatty acid synthesis. Furthermore, the levels of serum inflammatory cytokines and the mRNA expression of inflammatory markers in liver tissue were significantly decreased. In vitro cell experiments produced similar results.
Authors
- Ziqing Yang (ORCID: https://orcid.org/0000-0002-0492-0862)
- Chuan‐Hua Li (ORCID: https://orcid.org/0000-0001-6329-6193)
- Duanqin Liu
- Wu Lan (ORCID: https://orcid.org/0000-0002-0677-3085)
- Zhifeng Wang (ORCID: https://orcid.org/0000-0001-8470-888X)
- Wenhao Wang (ORCID: https://orcid.org/0000-0002-9369-9492)
- Yi-Fei Nie
- Wenqing Meng
- Kai Mao
- Huiping Ren
- Jing Lan (ORCID: https://orcid.org/0009-0004-3595-7467)
Institutions
- Shandong University (CN)
Publication Details
- Journal
- Molecular Medicine
- Published
- 2024-10-26
- DOI
- https://doi.org/10.1186/s10020-024-00945-1
- Citations
- 12
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 2.81
Funders
- National Natural Science Foundation of China
- Major Scientific and Technological Innovation Project of Shandong Province