GCN2-SLC7A11 axis coordinates autophagy, cell cycle and apoptosis and regulates cell growth in retinoblastoma upon arginine deprivation
Collectively, our findings suggest that the GCN2‒SLC7A11 axis regulates cell growth and survival upon arginine deprivation through coordinating autophagy, cell cycle arrest, and apoptosis in retinoblastoma cells. This work paves the way for the development of a novel treatment for retinoblastoma.
Authors
- Jason C. S. Yam (ORCID: https://orcid.org/0000-0002-2156-1486)
- Alisa S.W. Shum (ORCID: https://orcid.org/0000-0002-0389-3567)
- Wai Kit Chu (ORCID: https://orcid.org/0000-0003-2903-3247)
- Chi Pui Pang (ORCID: https://orcid.org/0000-0002-7764-6382)
- Yun‐Chung Leung (ORCID: https://orcid.org/0000-0003-3590-7027)
- Dan Wang (ORCID: https://orcid.org/0000-0002-9758-3614)
- Sun On Chan (ORCID: https://orcid.org/0000-0002-3221-3786)
Institutions
- Hong Kong Polytechnic University (HK)
- Chinese University of Hong Kong (HK)
- Hong Kong Eye Hospital (CN)
- Prince of Wales Hospital (CN)
Publication Details
- Journal
- Cancer & Metabolism
- Published
- 2024-10-26
- DOI
- https://doi.org/10.1186/s40170-024-00361-3
- Citations
- 5
- Primary Topic
- Cancer Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.93
Funders
- Health and Medical Research Fund