The association between aberrant salience and psychotic experiences in general population twins, and genetic vulnerability as a modifier
Various studies including the present could not replicate the association between aberrant salience and psychotic experiences in general population samples. The conflicting findings might be explained by moderation by genetic vulnerability, but results are inconsistent. If there was evidence for a main effect or interaction, this was in the positive symptom scale only. On the other hand, the association was more robust in so-called 'ultra-high risk' patients and first episode psychosis patients. Thus, this association may represent a state-dependent association, present only at the more severe end of the psychosis spectrum.
Authors
- Dina Collip (ORCID: https://orcid.org/0000-0002-2323-5780)
- Jim van Os (ORCID: https://orcid.org/0000-0002-7245-1586)
- Ruud van Winkel (ORCID: https://orcid.org/0000-0001-6262-1935)
- E Broggi (ORCID: https://orcid.org/0009-0003-5520-7770)
- Bart P. F. Rutten (ORCID: https://orcid.org/0000-0002-9834-6346)
- Nele Jacobs (ORCID: https://orcid.org/0000-0003-4021-4014)
- Marc D. Binder (ORCID: https://orcid.org/0000-0003-4255-5920)
- Marjan Drukker (ORCID: https://orcid.org/0000-0002-6346-2662)
- Claudia Menne‐Lothmann (ORCID: https://orcid.org/0000-0003-1121-5608)
- Jeroen Decoster (ORCID: https://orcid.org/0000-0001-8614-7000)
- Sinan Gülöksüz (ORCID: https://orcid.org/0000-0002-6626-1874)
- Cathérine Derom (ORCID: https://orcid.org/0000-0001-5574-796X)
- Tatvan Todor
- Mihika Kelkar
- Thomas Wigglesworth
- Kayle Verhiel
- Karel van Leeuwen
- Evert Thiery
- Jelle Bongaarts
- Meinte Koster
Institutions
- University of Antwerp (BE)
- King's College London (GB)
- Maastricht University Medical Centre (NL)
- Ghent University Hospital (BE)
- University Medical Center Utrecht (NL)
- Yale University (US)
- Maastricht University (NL)
- Kings Health Partners (GB)
- Open University of the Netherlands (NL)
- KU Leuven (BE)
Publication Details
- Journal
- BMC Psychiatry
- Published
- 2024-10-26
- DOI
- https://doi.org/10.1186/s12888-024-06176-2
- Citations
- 2
- Primary Topic
- Psychosomatic Disorders and Their Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.77