Genetic and Epidemiological Insights into <scp><i>RAB32</i></scp>‐Linked Parkinson's Disease
The RAB32 p.Ser71Arg variant defines a cluster of PD patients in northern Italy. Globally, it is most prevalent in MENA. Our data indicate that p.Ser71Arg causes PD and that it occurred only once, through a founder event. Other RAB32 variants are unlikely to cause PD. © 2024 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
Authors
- Francesco Cavallieri (ORCID: https://orcid.org/0000-0001-5836-1982)
- Franco Valzania (ORCID: https://orcid.org/0000-0003-4887-1692)
- Sabrina Lemke
- Ana Westenberger (ORCID: https://orcid.org/0000-0001-8062-6959)
- Christine Klein (ORCID: https://orcid.org/0000-0003-2102-3431)
- Michele Matarazzo (ORCID: https://orcid.org/0000-0002-2907-8667)
- Valentina Fioravanti (ORCID: https://orcid.org/0009-0003-4631-8591)
- Haşmet Hanağası (ORCID: https://orcid.org/0000-0002-4624-4428)
- Chiara Cerami (ORCID: https://orcid.org/0000-0003-1974-3421)
- Sven Thonke
- Mandy Radefeldt
- Enza Maria Valente (ORCID: https://orcid.org/0000-0002-0600-6820)
- Anna Negrotti
- Jefri Jeya Paul
- Peter Bauer (ORCID: https://orcid.org/0000-0003-2811-1354)
- Kridsadakorn Chaichoompu (ORCID: https://orcid.org/0000-0002-8123-3409)
- Christian Beetz (ORCID: https://orcid.org/0000-0001-7061-2895)
- Filipa Curado (ORCID: https://orcid.org/0000-0003-3311-0081)
- Micol Avenali (ORCID: https://orcid.org/0000-0002-7880-9921)
- Andrea Panzavolta
Institutions
- Goethe University Frankfurt (DE)
- University of Parma (IT)
- University of Pavia (IT)
- Azienda Sanitaria Unità Locale di Reggio Emilia (IT)
- Klinikum Hanau (DE)
- HM Hospitales (ES)
- Centogene (Germany) (DE)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Istanbul University (TR)
- University of Lübeck (DE)
Publication Details
- Journal
- Movement Disorders
- Published
- 2024-10-26
- DOI
- https://doi.org/10.1002/mds.30041
- Citations
- 11
- Primary Topic
- Nuclear Receptors and Signaling
- Type
- article
- Field-Weighted Citation Impact
- 2.95
Funders
- Denali Therapeutics