Shrinkage estimation of gene interaction networks in single-cell RNA sequencing data
The proposed framework broadens application of graphical model in scRNAseq analysis with flexibility in sparsity of count data resulting from dropout events, high performance, and fast computational time. Implementation of the framework is in a reproducible Snakemake workflow https://github.com/calathea24/ZINBGraphicalModel and R package ZINBStein https://github.com/calathea24/ZINBStein .
Authors
- Thomas Thorne (ORCID: https://orcid.org/0000-0002-7396-5116)
- Duong H.T. Vo (ORCID: https://orcid.org/0009-0002-1893-6635)
Institutions
- University of Surrey (GB)
Publication Details
- Journal
- BMC Bioinformatics
- Published
- 2024-10-26
- DOI
- https://doi.org/10.1186/s12859-024-05946-9
- Citations
- 2
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 0.47