α-Synuclein disrupts microglial autophagy through STAT1-dependent suppression of Ulk1 transcription
These findings reveal a novel mechanism by which α-Syn impairs microglial autophagy and indicate that targeting STAT1 or ULK1 may be a therapeutic strategy for PD.
Authors
- Hai‐Yue Tu
- Liang Ouyang (ORCID: https://orcid.org/0000-0001-5537-8834)
- Hai-Chun Qian
- Xiao‐Ou Hou
- Chong‐Shuang Pei
- Yang Li (ORCID: https://orcid.org/0000-0003-2845-5739)
- Chun‐Feng Liu (ORCID: https://orcid.org/0000-0002-8364-0219)
- Kai Li
- Junyi Liu (ORCID: https://orcid.org/0009-0005-6463-4488)
- Li‐Fang Hu (ORCID: https://orcid.org/0000-0001-8326-7779)
- Zhigui Ma (ORCID: https://orcid.org/0000-0003-2966-361X)
Institutions
- Sichuan University (CN)
- Soochow University (CN)
- Second Affiliated Hospital of Soochow University (CN)
- State Key Laboratory of Biotherapy
Publication Details
- Journal
- Journal of Neuroinflammation
- Published
- 2024-10-26
- DOI
- https://doi.org/10.1186/s12974-024-03268-4
- Citations
- 12
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 4.43
Funders
- National Natural Science Foundation of China