The role of the oral microbiota in the causal effect of adjunctive antibiotics on clinical outcomes in stage III–IV periodontitis patients
The shift towards a normobiotic subgingival microbiome, primarily induced by adjunctive antibiotics, underscores the potential for microbiome-targeted interventions to enhance therapeutic efficacy in chronic inflammatory conditions. This study reaffirms the importance of understanding the oral microbiome's role in periodontal health and paves the way for future research exploring personalized treatment strategies based on individual microbiome profiles. Video Abstract.
Authors
- Doğan Kaner
- Katrin Lorenz (ORCID: https://orcid.org/0000-0002-0228-6140)
- Peter Eickholz (ORCID: https://orcid.org/0000-0002-1655-8055)
- Ti‐Sun Kim
- Sven Kleine Bardenhorst (ORCID: https://orcid.org/0000-0002-7661-6931)
- Karola Prior
- Benjamin Ehmke (ORCID: https://orcid.org/0000-0002-2418-6765)
- Thomas Kocher (ORCID: https://orcid.org/0000-0001-9605-2822)
- Yvonne Jockel‐Schneider (ORCID: https://orcid.org/0000-0002-5646-3691)
- Daniel Hagenfeld (ORCID: https://orcid.org/0000-0003-1072-4865)
- Joerg Meyle (ORCID: https://orcid.org/0000-0003-0495-6926)
- Johannes Matern (ORCID: https://orcid.org/0000-0003-0679-5759)
- Dag Harmsen
- Inga Harks
Institutions
- Goethe University Frankfurt (DE)
- Witten/Herdecke University (DE)
- Justus-Liebig-Universität Gießen (DE)
- Heidelberg University (DE)
- University of Münster (DE)
- Universitätsmedizin Greifswald (DE)
- University Hospital Heidelberg (DE)
- University Hospital Münster (DE)
- Universitätsklinikum Würzburg (DE)
- Giessen School of Theology (DE)
- Technische Universität Dresden (DE)
- Charité - Universitätsmedizin Berlin (DE)
Publication Details
- Journal
- Microbiome
- Published
- 2024-10-26
- DOI
- https://doi.org/10.1186/s40168-024-01945-3
- Citations
- 10
- Primary Topic
- Oral microbiology and periodontitis research
- Type
- article
- Field-Weighted Citation Impact
- 4.00
Funders
- Deutsche Forschungsgemeinschaft