Development and preliminary evaluation of a novel preoperative index for quantitative analysis of photoreceptor loss in full-thickness macular holes
What is known Previous studies have extensively used optical coherence tomography (OCT) to investigate various biomarkers for assessing patients with full-thickness macular hole (FTMH), without considering detailed MH ultrastructural features Existing indexes used to predict surgical outcomes for FTMH primarily depend on geometrical parameters and do not integrate detailed ultrastructural characteristics, such as cellular components. What is new A novel concept introduces the quantitative measurement of residual photoreceptors located at the edge of FTMH. The Photoreceptor Integrity Index (PIIN) integrates different ultrastructural components of macular holes, aiming to become a valuable clinical tool to predict both anatomical and functional recovery outcomes following surgical intervention for FTMH.
Authors
- Matteo Gironi (ORCID: https://orcid.org/0000-0001-6923-0603)
- Alberto Quarta (ORCID: https://orcid.org/0000-0002-0818-6124)
- Maria Ludovica Ruggeri (ORCID: https://orcid.org/0000-0002-5856-6686)
- Mario Nubile
- Marta Di Nicola (ORCID: https://orcid.org/0000-0003-1748-1931)
- Luca Agnifili (ORCID: https://orcid.org/0000-0002-1625-6305)
- Annamaria Porreca (ORCID: https://orcid.org/0000-0003-3278-1561)
- Lisa Toto (ORCID: https://orcid.org/0000-0001-5311-5184)
- Andrea Govetto (ORCID: https://orcid.org/0000-0003-2192-810X)
- Rodolfo Mastropasqua (ORCID: https://orcid.org/0000-0003-1541-4735)
- Mario Rosario Romano (ORCID: https://orcid.org/0000-0003-0348-0532)
Institutions
- Humanitas University (IT)
- Ospedale di Circolo e Fondazione Macchi (IT)
- University of Chieti-Pescara (IT)
- Humanitas Gavazzeni (IT)
Publication Details
- Journal
- Graefe s Archive for Clinical and Experimental Ophthalmology
- Published
- 2024-10-26
- DOI
- https://doi.org/10.1007/s00417-024-06654-z
- Citations
- 4
- Primary Topic
- Retinal and Macular Surgery
- Type
- article
- Field-Weighted Citation Impact
- 1.62
Funders
- Università degli Studi G. d'Annunzio Chieti - Pescara