Synergistic effects of bacteriophage cocktail and antibiotics combinations against extensively drug-resistant Acinetobacter baumannii
The findings suggested that the bacteriophage cocktail is an effective tool in combating A. baumannii biofilms, with its efficacy depending on the concentration. Combining antibiotics with the bacteriophage cocktail improved the inhibition and removal of biofilms, indicating a promising strategy for managing A. baumannii infections. These results contribute to our understanding of biofilm dynamics and the potential of bacteriophage cocktails as a novel therapeutic approach to combat antibiotic-resistant bacteria.
Authors
- Salehe Sabouri (ORCID: https://orcid.org/0000-0002-9479-212X)
- Omid Tadjrobehkar (ORCID: https://orcid.org/0000-0002-5562-8079)
- Mohammad Samare‐Najaf (ORCID: https://orcid.org/0000-0002-1741-503X)
- Sanaz Rastegar (ORCID: https://orcid.org/0000-0001-9793-0092)
- Mikael Skurnik (ORCID: https://orcid.org/0000-0001-8791-9260)
- Hossein Hosseini-Nave (ORCID: https://orcid.org/0000-0002-9152-818X)
- Ali Samareh (ORCID: https://orcid.org/0000-0002-1234-7904)
- Maryam Khajedadian
- Zahra Lotfian (ORCID: https://orcid.org/0009-0009-7406-668X)
Institutions
- University of Helsinki (FI)
- Kerman University of Medical Sciences (IR)
- High Institute for Education and Research in Transfusion Medicine (IR)
Publication Details
- Journal
- BMC Infectious Diseases
- Published
- 2024-10-26
- DOI
- https://doi.org/10.1186/s12879-024-10081-0
- Citations
- 22
- Primary Topic
- Bacteriophages and microbial interactions
- Type
- article
- Field-Weighted Citation Impact
- 10.10
Funders
- Kerman University of Medical Sciences