Targeting FAP-positive chondrocytes in osteoarthritis: a novel lipid nanoparticle siRNA approach to mitigate cartilage degeneration
FAP-positive chondrocytes play a significant role in the pathogenesis of OA. Targeting these cells selectively has the potential to mitigate the progression of the disease. Our study provides valuable insights into the intraarticular injection of LNP@FAP siRNA as a promising strategy for the treatment of OA.
Authors
- M. Liu (ORCID: https://orcid.org/0009-0006-9900-8636)
- Yanzheng Gao (ORCID: https://orcid.org/0000-0002-2937-815X)
- Xiang Zhao (ORCID: https://orcid.org/0000-0002-9086-742X)
- Hongda Shao (ORCID: https://orcid.org/0000-0002-2331-3486)
- Chunhui Ma (ORCID: https://orcid.org/0000-0003-1146-0224)
- Ping Huang (ORCID: https://orcid.org/0009-0003-2742-7207)
- Jun Jiang (ORCID: https://orcid.org/0000-0002-5971-3174)
- Xin Li (ORCID: https://orcid.org/0000-0002-7138-0042)
- Jiajin Li (ORCID: https://orcid.org/0000-0003-1300-6025)
- Qingrong Xu
- Liang Yu (ORCID: https://orcid.org/0009-0007-3922-3454)
- Dongxin Jiang
- Bo Shi (ORCID: https://orcid.org/0000-0003-4661-2259)
- Jieming Lin
Institutions
- Henan University (CN)
- Shanghai Jiao Tong University (CN)
- Renji Hospital (CN)
- Zhengzhou University (CN)
- Nanjing Drum Tower Hospital (CN)
- Henan Provincial People's Hospital (CN)
- Shanghai First People's Hospital (CN)
Publication Details
- Journal
- Journal of Nanobiotechnology
- Published
- 2024-10-26
- DOI
- https://doi.org/10.1186/s12951-024-02946-y
- Citations
- 18
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 8.46
Funders
- Natural Science Foundation of Shanghai
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation