Zebrafish arterial valve development occurs through direct differentiation of second heart field progenitors
Our work highlights a conserved ancestral mechanism of arterial valve leaflet formation from the SHF and identifies that development of the arterial valve is distinct from that of the atrioventricular valve in zebrafish. Crucially, this confirms the utility of zebrafish for understanding the development of specific BAV subtypes and arterial valve dysplasia, offering potential for high-throughput variant testing.
Authors
- Lorraine Eley (ORCID: https://orcid.org/0000-0002-8094-2254)
- Christopher J. Derrick (ORCID: https://orcid.org/0000-0002-5008-3014)
- Deborah J. Henderson (ORCID: https://orcid.org/0000-0002-2705-5998)
- Ahlam Alqahtani (ORCID: https://orcid.org/0000-0003-1145-8474)
- Bill Chaudhry
Institutions
- Centre for Life (GB)
- University of Newcastle Australia (AU)
- Newcastle University (GB)
Publication Details
- Journal
- Cardiovascular Research
- Published
- 2024-10-25
- DOI
- https://doi.org/10.1093/cvr/cvae230
- Citations
- 5
- Primary Topic
- Congenital heart defects research
- Type
- article
- Field-Weighted Citation Impact
- 1.17
Funders
- British Heart Foundation