Mouse models of <i>Slc35a2</i> brain mosaicism reveal mechanisms of mild malformations of cortical development with oligodendroglial hyperplasia in epilepsy
This study presents two novel Slc35a2 conditional knockout mouse models and characterizes the effects on brain development, behavior, and epileptogenesis. Together, these results demonstrate a direct causal role for SLC35A2 in MOGHE-like phenotypes, including a critical role in neuronal migration during brain development, and identify neurons as key contributors to SLC35A2-related epileptogenesis.
Authors
- Hyojung Yoon (ORCID: https://orcid.org/0000-0002-1376-9527)
- Rachel Corrigan (ORCID: https://orcid.org/0000-0002-1248-1329)
- Lauren Mashburn‐Warren (ORCID: https://orcid.org/0000-0002-3698-4924)
- Cindy Huynh (ORCID: https://orcid.org/0000-0002-8505-2680)
- Sahibjot Sran (ORCID: https://orcid.org/0000-0001-7621-0619)
- Peter B. Crino (ORCID: https://orcid.org/0000-0002-6232-3740)
- Vincenzo Coppola (ORCID: https://orcid.org/0000-0001-6163-1779)
- Soad Elziny
- Amanda Ringland
- Foued Amari (ORCID: https://orcid.org/0000-0003-4904-877X)
- Tracy A. Bedrosian (ORCID: https://orcid.org/0000-0002-1051-9100)
- Noriyuki Shinagawa (ORCID: https://orcid.org/0000-0001-9658-7667)
- Min Chen (ORCID: https://orcid.org/0000-0002-0676-3143)
- James J. Anderson (ORCID: https://orcid.org/0009-0004-7326-5787)
- Samantha Badertscher
Institutions
- University of Maryland, Baltimore (US)
- Nationwide Children's Hospital (US)
- The Ohio State University (US)
Publication Details
- Journal
- Epilepsia
- Published
- 2024-10-26
- DOI
- https://doi.org/10.1111/epi.18166
- Citations
- 11
- Primary Topic
- Genetics and Neurodevelopmental Disorders
- Type
- article
- Field-Weighted Citation Impact
- 6.05
Funders
- Ohio State University
- National Institutes of Health
- National Institute of General Medical Sciences
- National Institute of Neurological Disorders and Stroke