ALDH2 mediates the effects of sodium-glucose cotransporter 2 inhibitors (SGLT2i) on improving cardiac remodeling
The upregulation of ALDH2 plays a critical role in the protection of DAPA against cardiac remodeling. DAPA enhances the binding of NFYA to the ALDH2 promoter by reducing the ALDH2 promoter methylation level through NHE1/ROS/DNMT1 pathway.
Authors
- Xilong Liu (ORCID: https://orcid.org/0009-0002-9875-8129)
- Yuguo Chen (ORCID: https://orcid.org/0000-0001-9501-2546)
- Bao Qiao
- Bin Jiang (ORCID: https://orcid.org/0000-0002-8229-2160)
- Qiuhuan Yuan (ORCID: https://orcid.org/0000-0002-4966-695X)
- Shujian Wei (ORCID: https://orcid.org/0000-0002-5906-5146)
- Han Liu (ORCID: https://orcid.org/0000-0002-6618-1380)
- Bailu Wang (ORCID: https://orcid.org/0000-0002-5420-9569)
- Rui Hua (ORCID: https://orcid.org/0000-0002-8856-5553)
- Xuehao Liu
- Xiangxin Zhang
- Wenjun Wang
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Shandong Provincial Hospital (CN)
- Ministry of Education (TH)
- Shandong Chest Hospital (CN)
- Qilu Hospital of Shandong University (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- Cardiovascular Diabetology
- Published
- 2024-10-26
- DOI
- https://doi.org/10.1186/s12933-024-02477-8
- Citations
- 7
- Primary Topic
- Heart Failure Treatment and Management
- Type
- article
- Field-Weighted Citation Impact
- 2.81
Funders
- Shandong University
- National Natural Science Foundation of China
- Natural Science Foundation of Shandong Province