Inhibitory Fcγ receptor deletion enhances CD8 T cell stemness increasing anti-PD-1 therapy responsiveness against glioblastoma
Deletion of FcγRIIB on CD8 T cells leads to the generation of a Ttsms, which is localized in TdLN and protected from the immunosuppressive TME. Incorporating these highly stemness-equipped Ttsms enhances the response to anti-PD-1 therapy in immune-suppressed brain tumors.
Authors
- In Kang (ORCID: https://orcid.org/0000-0002-9125-0528)
- Byeong Hoon Kang
- Keun Bon Ku (ORCID: https://orcid.org/0000-0003-0870-0995)
- Heung Kyu Lee (ORCID: https://orcid.org/0000-0002-3977-1510)
- Yumin Kim (ORCID: https://orcid.org/0000-0002-1648-6370)
- Jeongwoo La (ORCID: https://orcid.org/0000-0002-8153-7402)
- Stephen Ahn (ORCID: https://orcid.org/0000-0002-6854-1597)
- Won Hyung Park (ORCID: https://orcid.org/0000-0002-6824-2423)
- Chae Won Kim (ORCID: https://orcid.org/0000-0002-4875-4501)
- Sung Ki Lee (ORCID: https://orcid.org/0000-0002-6941-192X)
Institutions
- Korea Advanced Institute of Science and Technology (KR)
- Konyang University (KR)
- Korea Research Institute of Chemical Technology (KR)
- The Catholic University of Korea Seoul St. Mary's Hospital (KR)
- Catholic University of Korea (KR)
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2024-10-01
- DOI
- https://doi.org/10.1136/jitc-2024-009449
- Citations
- 8
- Primary Topic
- Monoclonal and Polyclonal Antibodies Research
- Type
- article
- Field-Weighted Citation Impact
- 3.23
Funders
- National Research Foundation
- National Research Foundation of Korea
- Samsung Science and Technology Foundation
- Samsung