Advancing continuous flow techniques in effective trimethoprim oxidation: combatting bacterial resistance in wastewater
This work describes an innovative catalytic process for aqueous trimethoprim degradation, using a fixed-bed continuous flow reactor packed with a manganese(III) <i>meso</i>-substituted porphyrin covalently immobilized functionalized aminopropyl silica gel as the catalyst and H<sub>2</sub>O<sub>2</sub> as a green oxidant. It exhibits remarkable activity and stability, maintaining its performance over extended periods (up to 8 hours) and achieving significant reductions in total organic carbon (TOC = 80%). Importantly, microbiological assays confirmed that this degradation process effectively converts trimethoprim into non-resistance-inducing products.
Authors
- Diana L. Marques (ORCID: https://orcid.org/0000-0002-5675-5934)
- Fábio M. S. Rodrigues (ORCID: https://orcid.org/0000-0002-1085-2720)
- Mariette M. Pereira (ORCID: https://orcid.org/0000-0003-4958-7677)
- Rafael T. Aroso (ORCID: https://orcid.org/0000-0002-2657-9212)
- Giusi Piccirillo (ORCID: https://orcid.org/0000-0003-1925-306X)
- Mário J. F. Calvete (ORCID: https://orcid.org/0000-0003-2094-4781)
- Gabriela Silva (ORCID: https://orcid.org/0000-0002-7479-8540)
- Lucas D. Dias
Institutions
- Universidade Evangelica de Goiás (BR)
- Infraestruturas de Portugal (Portugal) (PT)
- University of Coimbra (PT)
Publication Details
- Journal
- Chemical Communications
- Published
- 2024-10-26
- DOI
- https://doi.org/10.1039/d4cc04504a
- Citations
- 2
- Primary Topic
- Pharmaceutical and Antibiotic Environmental Impacts
- Type
- article
- Field-Weighted Citation Impact
- 0.27
Funders
- Foundation for Science and Technology