CHRDL1 inhibits OSCC metastasis via MAPK signaling-mediated inhibition of MED29
MED29 facilitated the epithelial-mesenchymal transition process in OSCC, thereby promoting migration and invasion. On the other hand, CHRDL1 exerted inhibitory effects on the invasion and metastasis of OSCC by suppressing MED29 through the inhibition of the MAPK signaling pathway.
Authors
- Songkai Huang
- Janak Lal. Pathak (ORCID: https://orcid.org/0000-0003-2576-443X)
- Junwei Zhang (ORCID: https://orcid.org/0000-0002-3138-9149)
- Jun Liang (ORCID: https://orcid.org/0000-0001-5112-583X)
- Zhengguo Piao
- Rui Zou (ORCID: https://orcid.org/0000-0002-6511-3191)
- Yu Qiao (ORCID: https://orcid.org/0000-0001-5945-4734)
- Si-Qing Xie
- Kexiong Ouyang (ORCID: https://orcid.org/0009-0004-1843-5181)
Institutions
- Sun Yat-sen University (CN)
- The Seventh Affiliated Hospital of Sun Yat-sen University (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Molecular Medicine
- Published
- 2024-10-26
- DOI
- https://doi.org/10.1186/s10020-024-00956-y
- Citations
- 7
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 2.00
Funders
- Guangzhou Medical University
- Australian Collaborative Education Network
- Guangzhou Municipal Science and Technology Bureau
- Guangzhou Municipal Science and Technology Project