The UCSC Genome Browser database: 2025 update
The UCSC Genome Browser (https://genome.ucsc.edu) is a widely utilized web-based tool for visualization and analysis of genomic data, encompassing over 4000 assemblies from diverse organisms. Since its release in 2001, it has become an essential resource for genomics and bioinformatics research. Annotation data available on Genome Browser includes both internally created and maintained tracks as well as custom tracks and track hubs provided by the research community. This last year's updates include over 25 new annotation tracks such as the gnomAD 4.1 track on the human GRCh38/hg38 assembly, the addition of three new public hubs, and significant expansions to the Genome Archive[GenArk) system for interacting with the enormous variety of assemblies. We have also made improvements to our interface, including updates to the browser graphic page, such as a new popup dialog feature that now displays item details without requiring navigation away from the main Genome Browser page. GenePred tracks have been upgraded with right-click options for zooming and precise navigation, along with enhanced mouseOver functions. Additional improvements include a new grouping feature for track hubs and hub description info links. A new tutorial focusing on Clinical Genetics has also been added to the UCSC Genome Browser.
Authors
- Clay Fischer
- Angie S. Hinrichs (ORCID: https://orcid.org/0000-0002-1697-1130)
- Gerardo Perez (ORCID: https://orcid.org/0009-0004-7658-2219)
- Charles Vaske (ORCID: https://orcid.org/0000-0001-8151-6612)
- W. James Kent
- Marijke J. van Baren (ORCID: https://orcid.org/0000-0002-1218-4527)
- Mark Diekhans (ORCID: https://orcid.org/0000-0002-0430-0989)
- Anna Benet‐Pagès (ORCID: https://orcid.org/0000-0001-6770-1299)
- Matthew L Speir (ORCID: https://orcid.org/0000-0002-2035-1129)
- Brian J. Raney (ORCID: https://orcid.org/0000-0002-9708-1390)
- Maximilian Haeussler (ORCID: https://orcid.org/0000-0001-8721-8253)
- Hiram Clawson (ORCID: https://orcid.org/0000-0002-0480-0545)
- Luis R Nassar (ORCID: https://orcid.org/0000-0002-6706-2586)
- Jairo Navarro Gonzalez (ORCID: https://orcid.org/0000-0003-4022-4829)
- D. Haussler
- Christopher M. Lee (ORCID: https://orcid.org/0000-0001-6574-3567)
- Jonathan D. Casper (ORCID: https://orcid.org/0009-0009-5722-1916)
- Galt P Barber
Institutions
- University of California, Santa Cruz (US)
- Helmholtz Zentrum München (DE)
- Medical Genetics Center (DE)
Publication Details
- Journal
- Nucleic Acids Research
- Published
- 2024-10-26
- DOI
- https://doi.org/10.1093/nar/gkae974
- Citations
- 500
- Primary Topic
- Genomics and Phylogenetic Studies
- Type
- article
- Field-Weighted Citation Impact
- 116.68
Funders
- U.S. Department of Health and Human Services
- California Institute for Regenerative Medicine
- California Department of Public Health
- National Institutes of Health
- Centers for Disease Control and Prevention
- National Institute of Mental Health
- National Human Genome Research Institute
- NIH Office of the Director