S-RBD-modified and miR-486-5p-engineered exosomes derived from mesenchymal stem cells suppress ferroptosis and alleviate radiation-induced lung injury and long-term pulmonary fibrosis
Engineered MSC exosomes with SARS-CoV-2-S-RBD- and miR-486-5p-modification were developed. MiR-486-RBD-MSC-Exo suppressed ferroptosis and fibrosis of MLE-12 cells in vitro, and alleviated RILI and long-term RIPF in ACE2 humanized mice in vivo. MiR-486-MSC-Exo exerted anti-fibrotic effects via SMAD2 inhibition and Akt activation. This study provides a potential approach for RIPF intervention.
Authors
- Huiyan Sun
- Yuxin Lu (ORCID: https://orcid.org/0000-0001-6587-2967)
- Fengjun Xiao (ORCID: https://orcid.org/0000-0003-4743-6146)
- Wen Li (ORCID: https://orcid.org/0000-0002-5499-1837)
- Lisheng Wang (ORCID: https://orcid.org/0000-0001-5965-308X)
- Yizhu Chen (ORCID: https://orcid.org/0000-0002-2579-3778)
- Tingting Liu (ORCID: https://orcid.org/0000-0002-3469-275X)
- Li Du (ORCID: https://orcid.org/0009-0002-0334-192X)
- Yang Sun
- Weiyuan Zhang
- Xiaochen Cheng
Institutions
- Qingdao University (CN)
- Jilin University (CN)
- Chinese PLA General Hospital (CN)
- Affiliated Hospital of Qingdao University (CN)
Publication Details
- Journal
- Journal of Nanobiotechnology
- Published
- 2024-10-26
- DOI
- https://doi.org/10.1186/s12951-024-02830-9
- Citations
- 49
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 11.46
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Hebei Province
- Natural Science Foundation of Shandong Province